Glutathione and its benefits are becoming more and more popular.
Although the body produces glutathione, a lot of products have come up marketing glutathione not as merely an antioxidant, but an anti-aging product and a whitening product as well. These products guarantee increasing further the levels of glutathione in your body, thus producing the desired effects. But are taking these glutathione supplements worth it?
Glutathione supplements are increasing in the market. These can be beneficial in the sense that it can improve the health and well-being of those that take these dietary supplements. Glutathione supplements are not direct glutathione compounds, meaning when you take a glutathione supplement, it is not glutathione per se that you are taking. Glutathione cannot enter cells directly and are only made from within the cell. The glutathione supplements are usually stimulators or accelerators, meaning they boost your body’s production of glutathione.
Upon the discovery of glutathione and its benefits as a natural antioxidant and detoxifier, enhancing the immune system and maintaining the body’s well-being, there has been a growing appeal to tap the ability to increase its synthesis within the body. This is achieved through dietary supplements. Glutathione supplements guarantee that they increase glutathione levels by supplying the basic components of glutathione formation.
Glutathione supplements are becoming in demand because of studies that show that increasing glutathione can lead to a healthier and better looking body. High glutathione levels are being related to good health and longer life, while low glutathione levels are being linked to diseases, aging, and other deteriorative effects. It is even said that there is an increased protection for cancer upon taking glutathione supplements.
Adding a glutathione accelerating supplement to your diet is an easy and effective way to acquire antioxidants your body needs to counteract the free radicals that accumulate in your cells. So take a glutathione supplement today! Prevention is always better than cure and this is one way to protect and promote a healthy body for yourself.
Want to know if glutathione supplements are worth it? For more information on the benefits of glutathione and glutathione promoting supplements, visit MaxOneMaxGXL.com.
Max Co-CEO Dave Bagley conducted an interview with Divine Health Wellness Center’s Director Dr. Don Colbert. Dr. Colbert specializes in integrative and anti-aging medicines. Read the transcript of the said interview below:
DB: Hi, I’m David Bagley, Co-Chief Executive Officer of Max International. As part of our special May 7th, launch program for Singapore, I conducted a recorded interview with Dr. Don Colbert, so that our Singapore associates could hear, from a leading medical professional, about the exciting nature of Max’s products and its core technology.
Dr. Don Colbert is the founder and medical director of Divine Health Wellness Center in Longwood, Florida. He is board certified in Family Medicine and specializes in anti-aging medicine, preventative medicine and integrative medicine.
Dr. Colbert is an expert on health and nutrition and is a highly regarded speaker who has appeared on Fox news, ABC World News, The BBC, Reader’s Digest, Newsweek and Prevention Magazine just to name a few. He is known internationally as a New York Times Best Selling author with over 40 book titles on health, nutrition and disease prevention that collectively have sold an excess of 8 million copies worldwide.
In 2011, Dr. Colbert earned a distinction of Double Diamond Level associate with Max International and has become one of the most outspoken proponents for Max’s products. Dr. Colbert, thank you for joining us today to welcome our Singapore associates as Max International expands in to Asia.
DC: Thank you Dave, it’s great being here.
DB: What lead you to medicine as your career choice, and tell us about the type of patients
that you see and perhaps your distinctive approach to patient care?
DC: Absolutely. First of all, I’ve been interested in health, all my life, since I was a kid. I used to read health books, muscle magazines, Jane Brody Collins, Jane Brody books, and so I’ve always been interested in health and diet, and I actually saw my uncle die of diabetes and had both his legs amputated and I said, my goodness if he wasn’t so fat, he could have kept his legs, he could have survived past his early 60′s and so it led me into medicine wanting to help people.
But then I found out in medicine that mainly what they do is just prescribe drugs and medications that simply treat the symptoms and not the disease and that’s when I switched more to integrative medicine where I used lifestyle, exercise, diet, nutrition, hormone replacement therapy, as well as we have a chiropractor in the office that addresses the structure component, we address the emotional component of the disease and I find that we can many times get to the root of the disease and clear the disease rather than treat the symptoms with medications.
DB: That’s fantastic. First of all, I applaud you for the fact that you do as all of the other people I’ve seen successful in integrating nutrition in their lives, they found a personal why and a reason to be able to do that which I think is absolutely critical. Let me ask you another question, why do you believe it’s important to support the body’s glutathione production and how do you think that that impacts health and wellness and anti-aging?
DC: Well, I discovered glutathione back about 20 years ago and the importance of glutathione, tried many different methods to raise it and nothing really worked well until I started using IV glutathione back about 5 to 10 years ago and I saw there were dramatic improvements in patients health, especially in Parkinson’s patients and made such a huge impact on me and I said, if we can only find a supplement that could boost glutathione levels, similar to the IV glutathione and give it to them on a daily basis to maintain those levels we’d find probably the best thing in order to help prevent and treat many of these diseases. So, I’ve understood the importance of glutathione, unlike most doctors who know nothing about glutathione but its the master antioxidant in the body, the most important antioxidant in the body for our cells and tissues to be healthy, we need glutathione levels and I actually measure glutathione levels in a lot of my patients and find when I can boost those levels up to a normal or high normal level, it helps so many different disease processes.
DB: When you’re taking a look at glutathione, I want to tap a little bit more about your history here because you have a unique background and understanding to this is that, perhaps you can shed some light of how, outside of IV glutathione and you start taking a look at potentially some supplements that could impact glutathione, prior to Max’s products being introduced to you what would you say would be the available ways of raising glutathione and what do you believe to had been their limitations from a supplemental angle?
DC: Well, interesting you know about over 10 years ago I went to Canada and I did some talks up there and I ran into a product that was called Immuno-cal which is a good product it is a undenatured whey protein with fragile proteins but it’s able to raise glutathione 35% and I thought that was phenomenal back then over 10 years ago and I started recommending that, but I had a lot of patients complain, first of all you couldn’t blend it, blending it will break down the fragile protein, you have to shake it, it was clumpy, it didn’t taste good, and I had a hard time getting patients to take it and I pretty much stopped that.
And then I started to using an alpha-lipolic acid and sure it helped some, it would raise glutathione anywhere from 30 to 70% but then we ran into limitations with that, it would lower blood sugar, people would get spacey, it’s great for diabetics, but for patients with normal blood sugar, many would react to it, it just didn’t helped them to the degree I thought it would but it did raise glutathione levels moderately.
I started using N-acetylcysteine , which we used in the ER when I practiced in the ER years ago, when I was in residency, I work in the ER and patients would come in Tylenol poisoning, we give them high doses of N-acetylcysteine like 10,000 mg, every 3 hours or so in order to reverse the effects of Tylenol poisoning and save their liver. And so we would give and expound on research that 8000 mg of N-acetylcysteine can raise the glutathione levels as much as 85%, but that’s taking 16 x 500mg capsules a day and its a nasty smelling supplement that patients just won’t do.
And so finally they came out with Max and Max is able to raise glutathione 300% and actually you can measure this and a double-blinded placebo controlled studies confirmed this, which is the goal standard here in the US for testing done. And I actually went out and measured glutathione levels on my patients and at a baseline, I see the boosting of glutathione that this product is able to boost it significantly in especially after the 60 days and I have to tell patients, you’ve got to take this 60 days because you will see the benefit.
Unfortunately some of my patients are so toxic, I have to warn them of detox reaction, because sometimes they may develop headaches, fatigue and things like that, which are detox reactions we have to cut back on the dosage so that they can overcome these detox reactions and I also have them drink more water, and what we find is a lot of our patients were called off because they can’t get in to see me for months and I’ll have one of the receptionists talk to them, let’s at least start you on the detox program, let’s start you on one of the Max products slowly, if you have these detox symptoms just cut back on it so in fact by doing that a lot of patients say, “hey after 60 days, I don’t have to see Dr. Colbert, I can cancel my appointment, I feel so great”.
DB: You mentioned something that was interesting, obviously you’re ability to be able to measure glutathione, to be able to monitor their improvement, track their progress, for those masses of people that don’t have access, either to a physician like yourself that can assist them in that or maybe they don’t have the wherewithall of it to be able to have the glutathione levels tested, what would you say would be a summary of what somebody could expect or at least understand what glutathione is doing for them without having access to testing?
DC: Well first of all, the double-blinded placebo controlled study shows that glutathione decreases inflammation. Inflammation is at the root of most diseases and they found that by boosting glutathione they can decrease the inflammatory marker Tumor necrosis factor-alpha by 41% and after 30 days which is great, but then 61% after 2 months or 60 days.
So glutathione decreases inflammation, it helps increase energy by protecting the mitochondria. The mitochondria are the little energy-producing factories in all our cells, every cell in the body has mitochondria, from fat cells, it might only have 2 mitochondria to heart muscle that may have 2,500 mitochondria, so what would we find is this actually protects the mitochondria from the oxidative stress because when the body produces ATP, which is our energy currency, its similar to producing smoke, its like when you’re burning fire in a fireplace, it produces smoke, but the body produces free radicals that would produce energy. And what the glutathione does it quenches these free radicals so it helps to protect the mitochondria enabling it to produce energy.
So, producing energy is a major thing most of my patients need, because so many people come and say I’m tired, I’m exhausted. Also what glutathione does it detoxes heavy metals and everyone on this planet has these toxic heavy metals in them. I find the sicker the patient, generally the more toxic metal and glutathione actually gently detoxes the body of this heavy metals including mercury, cadmium and lead which are three of the most common heavy metals we have as well as other toxic metals.
Glutathione also helps to improve our immune system. It helps to literally boost our WBC’s or white blood cells as well as natural killer cells and natural killer cells are important in killing viruses, bacteria and even killing cancer cells.
It’s interesting too that glutathione also helps increase longevity, they’ve done centenarian studies on patients who live to be over a hundred and they found a lot of these centenarians actually have the glutathione levels of a 30 to 50 year old. So they are linking high glutathione levels to longevity.
So again, these are just a few things and the biggest thing though is what it does throughout the body. Everyday we form these free radicals and these free radicals form in or brain, in our heart, in our kidneys, in our liver, in our lungs and they damage these tissues and eventually degenerate these tissues, but by keeping the glutathione levels high, you’re protecting the five most important organs in the body.
And again, heart disease is the number one killer here in the US, but realize that cancer is the number 2 killer. And by keeping these tissues and cells healthy, by keeping the immune system strong, by decreasing inflammation, by preventing the build up of these toxic heavy metals, and excreting these toxic heavy metals, we are protecting our bodies from the worst diseases where most people die such as the heart disease and the cancer, as well as other degenerative diseases.
DB: You touched on a couple of things there that I find absolutely intriguing and it reminds me the time I had conversation with Dr. Nagasawa and we were discussing how important it was as well as with his son Dr. Scott Nagasawa, about, we take a look at the concentrations of glutathione levels in the body and you are taking a look that they are in its highest concentrations in these essential organs that you’re talking about, the heart, the lungs, the kidney, the liver, the brain, even in the eyes, the ears, these areas of our body, specially the skin, these are the areas of our body that are most prone to the highest levels of stress or toxins, that’s where glutathione is working overtime in our best interest and you have those little a-ha moments by saying, if it’s important enough to my body to have those housed, in the most critical organs and areas in my body, it’s probably something I should pay attention to.
DC: Absolutely. And what’s so important too, Dave, is that I realized that the majority of these chronic diseases, have at their root inflammation. Realize that most heart disease is inflammatory in its root. Cancer is usually inflammatory, Alzeihmer’s disease is inflammatory, arthritis is inflammatory, auto-immune diseases is including lupus and rheumatoid arthritis and thyroiditis and MS, they all have at their root, inflammation.
So again, when you boost glutathione levels, you are decreasing inflammation, you are quenching free radicals and as a result of doing that we usually see dramatic improvements in patients.
DB: Yes, it’s not surprising, you know we take a look at the number of people out there who, obviously, we live in a society today where the amount of stressors that are taking a toll on our body are more now that what they ever have been which raises the question, what more do I need to do to help counteract this increased amount of environmental or dietary or even emotional stressors that are out there or as you take a look at it, it’s amazing to see the design of the body and there is such a thing as important and as powerful and as broad spectrum as glutathione and it’s obviously one of those things that we need to be paying attention to and it’s fun to be a part of that quest.
In fact when you’re talking with people that are new into your office or somebody that you come across at a dinner table or whatever, how was it that you would briefly, or elementarily explain what glutathione is.
DC: What I just tell them, is that glutathione is first of all a master antioxidant and I don’t try and get into a lot of the science, but I am just trying to explain tot hem that pretty much every tissue and organ in the body needs adequate amounts of glutathione in order to function properly and the powerful results of it, it decreases inflammation, I’d explain that again, inflammation is the root of the most chronic diseases and many of the patients I see have a chronic disease and I show them and I say, for this amount of money, we can test your glutathione levels and see it also increases energy in almost every patient wants to have more energy because they’re tired.
And the other thing it does, it helps with stress by enabling people to enter into that deeper sleep and say it will actually help improve sleep architecture and many of my patients when they boost the glutathione levels and it helps with the adrenals and this is what a lot of people don’t understand that so many of my patients have what we call adrenal fatigue, where their adrenaline glands are just chronically in the state of fatigue and as a result these people suffer from tiredness and fatigue and what the glutathione does, just what it does in the brain and the heart and the kidneys and the lungs and the liver, it helps with the, put the inflammation out of the adrenals, which enables the adrenals to function better and many these patients with adrenal fatigue see an improvement in their ability they cope with stress and in their ability to sleep. So in other words, we have patients with adrenal fatigue improve dramatically when glutathione levels are boosted.
DB: When you’re talking about that, obviously somebody’s going to be intrigued, I think that they should be more than intrigued, they should figure it out that hey, that seems to be important to me, what’s the solution, when you talk about MaxOne, how is that you explain what it is to them?
DC: Well, what I explain is that, first of all, it’s a simple molecule that’s made of L-Cysteine and D-Ribose and L-Cysteine is a fragile molecule that enters the digestive tract coz again if it’s not bound with D-Ribose and it’s not absorbed well, it’s destroyed but similar to N- acetylcysteine so again, with this new molecule, it’s easily absorbed, it’s easily assimilated and used as a raw material to produce glutathione and again, the glutathione is the most important molecule.
You can’t take glutathione and expect to raise your glutathione because the majority of that is destroyed in the digestive tract and the body has to literally rebuild the molecule, yet the majority destroyed.
So with this new molecule, we actually have, we found that we can increase the glutathione significantly and that’s the exciting part of it and it’s just one capsule twice a day, which very easy dosing because so many people are non compliant. If they’re going to take 10 or 20 capsules twice a day, they’re not going to do it but just one capsule twice a day is real easy for the majority of my patients.
DB: Who do you think needs to be aware of what glutathione plays a role in doing for the body everyday as well as being aware of MaxOne. I mean is it just people that would find themselves in your office or people that are out and about everyday, who would you recommend needs to know about these products.
DC: Well, realize that after age 21, out glutathione levels diminish by one percent per year and so anyone I’d say over 21 and especially I would say professional collegiate athletes because what this is also when you boost glutathione levels, is increasing stamina, is increasing muscle recovery and anyone who wants to protect these organs and wants to live a long healthy life and prevent many diseases that are associated with low glutathione levels.
So I tell pretty much anyone over there over 21, should seriously consider it and any athlete under 21 that are real competitive, should be on this also.
DB: Dr. Colbert, I know that a lot of nutritional companies because of your background, your level of influence and the level of respect that you carry, have tried to do everything to get you to represent their product, so what was different about Max to where you wanted to be a part of this program?
DC: Well, first of all, there are so many nutritional companies, that are knock-offs of other companies and they don’t have the double-blind placebo controlled studies I recognize the most important nutrient in the body is glutathione. And finally we have a product that’s able to show conclusively that it boost glutathione levels as much as 300% and so, again, I recognize the most degenerative disease are inflammatory based and this product decreases inflammation as well as it’s a powerful antioxidant and most diseases that we see are associated with low glutathione levels even ADHD in children, generally they have low glutathione and so glutathione is probably the basis of protection against many diseases and unfortunately, the very people who should be recommending it, who are doctors, know nothing about it.
And I’ve been studying nutrition for so many years I understand the importance of this and so I recognize it immediately. Hey, this is something huge and the public needs to be made aware of this because this I believe is the most incredible nutraceutical discovery in my lifetime and unfortunately most doctors know nothing about it or they’re just not aware because they are being trained by the pharmaceutical industry.
DB: You touched on something that I remind myself every single day and how unique it is for us to be a group that has the opportunity to represent a breakthrough discovery like what Dr. Nagasawa has done with The National Institutes of Health, The Veteran’s Administration in nearly 30 years in discovery and perfection of a way to be able to protect that fragile cysteine molecule and do it in a way that’s received naturally by the body. It’s absolutely amazing to be able to be a part of that and you mentioned about the number of people that are unaware of what glutathione is. I mean, do you see that changing anytime in the near future? People’s awareness of and what is glutathione?
DC: Well, again, we are seeing such incredible testimonies in my practice and the best way is the ground root’s effort.
When patient’s are literally feeling so much better and have huge improvement in their health, again we are going to finally see doctor’s take notice and they’re going to say, hey wait, that weren’t my medicine that did that? What are you doing?
And so Again, I think that it’s going to take people going to their doctors and say hey, you need to look at this, you need to see what this is about and then eventually news crews come out, maybe Fox News, other news stations come out and get testimonies and show how simply the power of glutathione is helping to change the health of so many patients.
That’s what I think will eventually happen, but people are still unaware of the power of glutathione and again, this message has got to get out about the power of glutathione.
DB: Yeah, you’ve mentioned something here and perhaps his is an appropriate place to have our final question here Dr. Colbert and that is as a double diamond leader with Max, what would you say to the new associates who have the opportunity to partner with Max and bringing these products to the world.
DC: Well, what’s so amazing is the world is totally unaware of the power of glutathione and this is so ground floor.
I’m so excited that this is such a young company with such a powerful supplement that will literally revolutionize; I believe the health of the world, in people who use this consistently.
And so, I’m excited for anyone who catches this opportunity because this is truly a product that’s unlike any other product I have ever seen in my entire life and so pretty much everyone of my patients goes on one of the Max products and it’s just an opportunity for anyone who catches this vision and understands the power of glutathione.
It’s interesting to see there’s almost 95,000 articles published on PubMed about the power of glutathione and so again if people would just tap into some of that research and catch a glimpse of the power of this and what we have the opportunity that you have, then I think it’s going to be a great motivational tool for anyone.
DB: Well, you said it appropriately, I obviously agree with everything that you mentioned there and we are honored to have somebody like yourself as a part of our Max family and being able to help spread the good word about a compound that we believe that the body is looking for and we appreciate everything that you’re doing in helping us move forward that cause and that purpose and Dr. Colbert, I want to thank you for your time today.
Glutathione is a substance that can be found within the cells of your body.
It is essential because it maintains proper functions and activities of your body. Like vitamin C and vitamin E, it is an antioxidant that can help eliminate free radicals. These free radicals are harmful substances that cause damages to different systems of your body. It is also a detoxifier that converts toxic substances into soluble, nontoxic substances that can be easily removed out of your body. It also has the ability to boost your immune system. With this, your body is more protected and resistant against diseases caused by infections and aging. What are the diseases that glutathione can protect us from? Most of the diseases that protect us from are chronic diseases such as cancer and heart diseases and infections caused by viruses and bacteria. It also protects as from inflammation and Parkinson’s disease.
What can glutathione do for your skin?
Mega doses of glutathione are good for your skin because it has anti-aging effects which could make you look younger than your age. More importantly, it is used by many people to whiten and lighten their complexion. How does it whiten your skin? Whitening effect of glutathione is due to its ability to inhibit an enzyme called tyrosinase that is essential for melanin formation. Melanin is the pigment involved in the dark coloration of your skin. Using glutathione to inhibit its formation would gradually result to a whiter and fairer skin that you always wanted to have.
What are the things that you should remember while taking glutathione?
Glutathione is safe and effective. You do not need to worry about any side effects because it doesn’t have any. You just have to avoid taking it with any anti-psychotic drug. It is also a must to take vitamin C because it converts glutathione to its active form or reduced form that renders it to become more absorbable in your body. In choosing what kind of glutathione product you should use, you should know that injectable glutathione is more superior to any other forms of glutathione because of its ability to increase the body’s glutathione levels.
To know more about glutathione, visit MaxOneMaxGXL.com
This article will demonstrate to you why Glutathione is so important to your health and well-being.
Glutathione (pronounced ‘gloota-thigh-own’) is the body’s essential health ABC’s – Antioxidant, Blood Booster and Cell Detoxifier.
It is a tripeptide composed of glutamic, cysteine and glycine. Glutathione is found in all cells in the body, including the bile, the epithelial lining fluid of the lungs, and – at much smaller concentrations – in the blood.
Glutathione is the smallest intracellular protein thiol (molecule containing an S_H or sulfhydryl group) molecule in the cells. This characteristic emphasizes its potent antioxidant action and supports a multifaceted thiol exchange system, which regulates cell activity. This small protein, produced naturally in the body, maintains these three crucial protective functions.
In fact, your life depends on glutathione. Without it, your cells would disintegrate from unrestrained oxidation, your body would have little resistance to metabolic acids, and your liver would shrivel up from the eventual accumulation of acidic toxins.
Glutathione is not yet a household word. Even some medical and holistic doctors who have heard the term may still have only a vague idea of what it is. However, everyone will soon be talking about this critical non-nutritive substance.
There was a time when only scientists had heard of cholesterol and vitamins, but today, everyone knows about them. Now the magnificence of glutathione is becoming known.
In the last five years, over 25,000 medical articles about this substance have been published, and the scientific understanding of glutathione is gradually becoming common knowledge.
Each and every cell in the body is responsible for its own supply of glutathione and must have the necessary raw materials in order to produce it.
Glutathione is always in great demand and is rapidly consumed when we
experience any sort of emotional or physical stress, fatigue and even
Some well-known causes of glutathione depletion are as follows:
- Acidic lifestyle and diet
- Air and Water pollution
- Prescription and recreational drugs
- Ultraviolet and Radiation from cells phones, computers, electrical cars, power lines, hair dryers, etc.
- Emotional and physical stress
- Injury, trauma or burns
- Heavy metals
- Cigarette smoke
- Household chemicals
- Acetaminophen poisoning
- Exhaust from motor vehicles
- Septic shock
All of these above factors lead to a build up of acidic toxins that cause the loss of glutathione as a non-nutritive buffer leading to cellular aging, disease and finally death.
Why is Glutathione Essential to Health?
Glutathione’s three major roles in the body are summarized by the letters A-B-C.
- Blood Booster
- Cell Detoxifier
These are the three critical processes driven by glutathione.
The Master Antioxidant
Over the past thirty years, researchers have explored the role of antioxidants in good health as well as the treatment and prevention of diseases involving oxidation or fermentation by metabolic acids.
Well known and widely used antioxidants such as vitamin A, vitamin E and selenium neutralize acid. They occur naturally in nature, but not in the body. They must be introduced as part of a balanced diet.
Given the critical role of antioxidants in good health, it is not surprising that the body itself manufactures its own natural antioxidants.
The most important of these is glutathione. Because all other antioxidants depend upon the presence of glutathione to function properly, scientists call it ‘the master antioxidant.’
Glutathione binds to toxins, forming a water-soluble complex – which is ultimately excreted in the urine or bile as waste.
Food for the Blood
Elevated glutathione levels enable the body to produce more white blood cells. White blood cells are the body’s garbage collectors and are the most important cells for maintaining sterility of the body fluids.
Glutathione plays a central role in the proper function of the white blood cells. Dr. Bustavo Bounous, a leading glutathione expert, says, ‘The limiting factor in the proper activity of our lymphocytes (the white blood cells) is the availability of glutathione.’ In other words, healthy growth and activity of the white blood cells depends upon glutathione’s availability. Put simply, glutathione is ‘food’ for the white blood cells.
Whether we know it or not, we are continually inhaling and ingesting natural and synthetic acidic toxins. They are unavoidable in these modern times both in our polluted cities and our poorly engineered food supplies. When the body has the health and the nourishment it needs, it works tirelessly to eliminate acidic toxins and to protect itself. But, increasing levels of environmental pollution are depleting the body’s store of glutathione more and more rapidly.
Our main organ of detoxification of acidic waste products is the lymphatic
system and the liver. This is the body’s most concentrated source of glutathione.
Studies show that low glutathione levels lead to poor lymphatic and liver function, causing more and more acidic toxins to circulate through the body and resulting in damage to individual cells and organs.
Medical doctors today routinely use glutathione- promoting drugs to detoxify victims of certain types of drug overdose.
Glutathione in Natural Medicine
Practitioners of complementary and alternative medicine (CAM) have long advocated the use of milk thistle for liver problems. It turns out that this herb works by modestly elevating glutathione levels. The mineral selenium also produces subtle elevations in glutathione by becoming integrated into the glutathione peroxidase.
Glutathione in Traditional Medicine
Emergency medical doctors, toxicologists and lung and liver specialists are well acquainted with glutathione’s therapeutic uses. American physicians seeking ways to raise a patient’s glutathione levels can open the standard Physician’s Desk Reference (PDR) and find two options – the pharmaceutical drugs sold under the names Parlodex and Mucomyst, and the natural dietary supplement found in natural foods stores derived from whey protein isolate.
Drugs That Raise Glutathione Levels
Pharmaceutical drugs like Procysteine, OTC, OTX, Glutathione monoesters and Glutathione diesters have been used to raise glutathione levels. However, they all produce side effects and are unsuitable for long term use.
This pharmaceutical non-nutritive chemical is used to break up mucus in lung
diseases such as cystic fibrosis, chronic bronchitis and asthma. It remains the
standard treatment for acetaminophen overdose.
Glutathione in Health and Disease
It is believed that glutathione has an important role to play in the prevention and treatment of disease. It may in the future be considered as important to health as an alkaline diet, exercise and alkaline lifestyle. Clinical tests show that raised glutathione levels may address some of the eight major health issues of our time:
- Prevents heart disease – Shimizu H, Kiyohara Y, Kitazono T, Kubo M,
Ibayashi S, Fufishima M, Lida M. Relationship Between Plasma Glutathione Levels and Cardiovascular Disease in a Defined Population: The Hisyama Study. Stroke. 2004 Sep; 35(9):2072-7.
- Prevents stroke – Paterson PG, Juurlink BH.
Nutritional Regulation of Glutathione in Stroke.
Neurtox Res. 1999 Dec; 1(2): 99-112.
- Prevents atherosclerosis – Coppola L, Grassia A, Giunta R. Glutathione
Improves Hemostatic and Hemorrheological Parameters in Atherosclerotic
Subject. Drugs Exp. Clin Res 1992
- Reverses artherosclerosis
- Prevents reperfusion injury
Cancer causing polychlorinated biphenyls (PCBs) have been found to alter levels of glutathione compounds in experiments, which may alter the body’s resistance to certain types of cancer.
Glutathione deficiencies have been linked to many forms of cancer.
- Prevents cancerous tissue
- Suppresses tumor growth
- Eliminates carcinogen
- acids – Retards oxidative stress
- Prevents wasting disease
- Eases side effects of chemotherapy and radiotherapy
Glutathione is the most efficient free radical (acid) scavenger in the airways, and dozens of studies have confirmed that free radical (acid) damage is a primary player in Chronic Obstructive Pulmonary Disease. Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54. – Breaks up mucus – Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54
- Breaks up mucus – Rahman I, MacNee W.
Oxidative Stress and Regulation of Glutathione in Lung Inflammation.
Eur Respir J. 2000 Sep; 16(3):534-54
- Cystic fibrosis – Glutathione neutralized harmful oxidants introduced into the lungs or those released by cells. Exotoxins from bacteria can overload the endobronchial terrain and feed the fires of acidic inflammation. This staggering burden increases the oxidative sensitivity of the CF lung, resulting in further injury of lung parenchyma. Data supports evidence of a decrease in the antioxidant tri-peptide glutathione (Roum JH, Buhl R, McElvaney NG, et al.
Systemic Deficiency of Glutathione in Systic Fibrosis. J Appl Physiol 1993; 75:19-24).
- Chronic bronchitis
- Emphysema – Lamson, David, MD, Grignall, Matthew, ND. The use of Nebulized Glutathione in the Treatment of Emphysema: A Case Report. Altern Med Review. 5(5);429-431, 2000 Oct.
Glutathione is critically important to our brain as it is one of the most important brain antioxidants. Glutathione helps preserve brain tissue by preventing damage from free radicals (acids).
In addition to quenching dangerous acids, glutathione also acts to recycle vitamin E which also has the ability to reduce acidity in the brain.
(Perlmutter D., BrainRecovery.com July 2004, 5th ed:13)
- Autism – Medical literature documents that an out-fection can lead to a lowering of glutathione which participates in detoxification, interacts with metallothioneins, and supports many crucial aspects of immunity. A link between glutathione and autism regression may derive from the fact that transient or chronic intestinal problems can impair an infant’s or toddler’s nutritional status, thereby minimizing the levels of amino-acids required for the production of glutathione (McCandless, J. Children With Starving Brains. 2003, 2nd ed; 252)
- Parkinson’s Disease – Glutathione helps to preserve brain tissue by preventing damage from free radicals (acids) and destructive chemicals formed by the normal processes of metabolism, toxic elements in the environment, and as a normal response of the body to challenges by acidic agents or other stresses. With the understanding that glutathione is important for brain protection and that this protection many be lacking in the brains of Parkinson’s clients due to glutathione deficiency, it can be seen as very beneficial. (Di Monte DA, Cahn P, Sandy MS. Glutathione in Parkinson’s Disease: A Link Between Oxidative Stress and Mitochondrial Damage? An Neurol. 32 Suppl; S111- 115, 1992.)
- Alzheimer’s Dis-ease – Woltjer, R.L., Hgheim W., Maezawa I., Vaisar T, Montine K.S., Montine T.J., Role of Glutathione in Intracellular Amyloid-Alpha Recursor Protein/Carboxy- Terminal Fragment Aggregation and Associated Cytotoxicity. J Neurochem. 2005 May; 93 (4): 1047-56.
- Huntington’s DisEase – Choo Y.S., Mao Z, Johnson GV, Lesort M. Increased Glutathione Levels In Cortical Striatal Mitochondria of the R6/2 Huntington’s Disease Mouse Model. Neuroscience Letter. 2005 Sep 23; 386(1): 63-8.
- Multiple Sclerosis – Calabrese V, Scapaginini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM. Disruption of 6 Thiol Homeostasis and Nitrostative Stress in the Cerebrospinal Fluid of Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine. 2003 Sep; 28(9):
1321-8. Mann CL, Davies MB, Aldersea J,
Fryer AA, Jones PK, Ko Ko C, Young C,
Strange RC, Hawkins CP. Glutathione
S-Transferase Polymorphisms in MS:
Their Relationship to Disability. Neurology.
2000 Feb 8;54(3):542-7.
- ALS – Tohgi H, Abe T, Yamazaki K, Murata T, Ishizake E, Isobe C. Increase
in Oxidized Products and Reduction in Oxidized Glutathione in Cerborospinal
Fluid From Patients with Sporadic Form of Amyotrophic Lateral Sclerosis.
Neurosci Lett. 1999 Feb 5; 260(3):204-6.
- Cataract formation
- Macular degeneration
- Cancers of aging
- Prostate problems
- Osteoarthritis – Hammarqvist F, Luo JL, cotgreave IA, Andersson K, Wernerman J. Skeletal Muscle Glutathione is Depleted In Critically Ill Patients. Crit Care Med. 25(1):78-84 1997 Jan.
- Inflammatory bowel dis-ease
- Peptic ulcer
- Detoxifies certain drug overdoses – Acetaminophen has been shown to reduce glutathione production, thus paving the way for enhanced brain destruction by metabolic acids. (Perlmutter D. July 2004, 5th ed:108)
- Detoxifies substances in cigarette smoke and auto exhaust – Rahman I, MacNee W.
Lung Glutathione and Oxidative Stress:
Implications In Cigarette Smoke-Induced Airway Disease. Am J Physiol. 277(6 Pt 1);1067-88,
- Detoxifies pollutants including heavy metals and pesticides Ã¢â‚¬â€œ Elevated glutathione levels have been shown to protect tissue form lipid peroxidation created by exposure to certain metals. Consider infusions of glutathione to relieve the body burden of both neurotoxins and metal toxicity, including mercury. (Foster, JS. Kane PC, Speight N. The Detoxx Book. 2002;90)
- Prevents hearing loss from noise pollution
- Detoxifies many well-known carcinogens
- Anti-viral for AIDS, hepatitis, herpes, etc. – Low glutathione levels in HIV clients may contribute to their immune deficiency since glutathione plays an important role in the function of lymphocytes. Some lymphocytes require adequate levels of glutathione in order to function normally, and HIV induces oxidative stress that depletes the cells of glutathione.
Townsend DM, Tew KD, Tapero H.
The Importance of Glutathione in Human
Disease. Biomed Pharmacother. 2003
May-June;57(3-4):145-55. Droge W, Holm E.
Role of Cysteine and Glutathione in HIV
Infection and other Diseases Associated with Muscle Wasting and
FASEB J, 11(13):1077-89 1997 Nov.
- Lyme Dis-Ease – Lyme dis-ease is a seriously complex multi-system acidic inflammatory condition that is triggered by bacterial exotoxins. Glutathione helps to remove exotoxic and/or mycotoxic acids by forming a soluble compound with them, which can then be excreted through the urine or gut. (Can Glutathione Help Lyme Disease Suffers?
Excerpt from: The Glutathione Report: Optimal Health with the Master Antioxidant, Issue 4, Volume 1, May 2004).
- Natural antibiotic
- Chronic fatigue syndrome – An article in the journal of Medical Hypothesis proposed that glutathione, an antioxidant essential for lymphocyte function, may be depleted in Chronic Fatigue Syndrome patients. Glutathione is needed for both the immune system and for aerobic muscular contraction. The authors proposed that glutathione depletion by an activated immune system also causes the muscular fatigue and myalgia associated with Chronic Fatigue Syndrome (Bounous et al. 1999).
- Athletic enhancement
- Decreases recovery time from physical stress
- Supports hemoglobin in kidney failure
- Diabetes – The blood and tissues of diabetics are marked by critically low
glutathione levels. Glutathione depletion may have adverse consequences in diabetic clients independent of glycemic control, and it may weaken the defense against oxidative stress.
De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C,
Falsano F. Influence of Reduced Glutathione Infusion on Glucose Metabolism in Patients with Non-insulin Dependent Diabetes Mellitus. Metabolism.
Glutathione provides the body with tools to fight off these threats naturally. Healthy people also benefit from elevated glutathione levels through an enhanced ability to fight off acidic toxins, dis-ease, pre-cancerous cells and the aging process itself. Diminished glutathione levels are a symptom of aging and are particularly evident in such alimentsas Parkinson’s dis-ease and Alzheimer’s dis-ease.
Glutathione is also important to physically active people. Many world-class athletes are discovering that well-maintained glutathione levels gives them the edge over their competitors, bringing greater strength and endurance,decreased recovery time from injury, less muscle pain and fatigue, and muscle-promoting activity.
Putting It All Together
1) Medical science is still ascertaining all the critical roles played by glutathione in disease resistance and general good health. Clinical evidence links low glutathione levels to the most common illnesses of our time as well as newly emerging diseases.
2) As an essential aid to health, glutathione works as the master antioxidant in our body, optimizes the white blood cells and detoxifies a long list of pollutants and carcinogens or acids. The best way to raise glutathione levels is by eating foods that are high in glutathione such as avocados.
3) Pharmaceutical medicine has created drugs that do this very effectively. They have their uses in critical situations. But they also have side effects and repeated use is clearly inadvisable.
It is well known that aging is accompanied by a precipitous fall in glutathione levels. Lower glutathione levels are implicated in many diseases associated with aging including cataracts, Alzheimer’s, Parkinson’s atherosclerosis and others.
Journal of Clinical Epidemiology 47:1021-26, 1994.
Antioxidants are well documented and known to play vital roles in health maintenance and dis-ease prevention. Glutathione is your cell’s own major antioxidant. Maintaining elevated glutathione levels aids the body’s natural antioxidant function.
Biochemical Pharmacology 47: 2114-2123, 1994.
Low glutathione levels have been associated with neuro-degenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig’s Dis-ease), Alzheimer’s and Parkinson’s. The Lancet 344: 796-798, 1994.
Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/antitumor defenses.
Cancer Letters 57: 91-94, 1991.
Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge.
Journal of Applied Physiology 87: 1381-1385, 1999.
Toxins, Pollution and Radiation
Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer.
Annual Reviews of Biochemistry 52: 711-760, 1983
Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS.
Proceedings of the National Academy of Science, USA 94: 1967-72, 1997.
Heart Dis-Ease, Stroke and Cholesterol
Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes.
Nutrition Reviews 54: 1-30, 1996.
Diabetics are more prone to ‘out-fections’ and circulatory problems leading
to heart disease, kidney failure and blindness. Glutathione protects
against the complications of diabetes.
Clinical Science 91:575-582, 1996
Doctors have used glutathione-promoting drugs to treat many lung diseases
including asthma, chronic bronchitis and emphysema. New and potentially
therapeutic roles can be found for cigarette smoke damage, pulmonary
fibrosis and other illnesses.
American Journal of Medical Science 307:119-127, 1994
Glutathione protects the body from inflammation of gastritis, stomach ulcers,
pancreatitis and inflammatory bowel dis-ease including ulcerative colitis and Crohn’s dis-ease.
Gut 42: 485-492, 1998
The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raisied glutathione levels help restore liver function.
American Journal of gastroenterology 91: 2569-2573, 1996
Those with kidney failure or on dialysis suffer from high levels of oxidative (acidic) stress and decreased glutathione levels. Raised glutathione levels help prevent anemia.
Nephron 61: 404-408, 1992
Pregnancy, Lactation and Childbirth
Glutathione’s role in fetal and placental development is critical. It also acts in the placenta to detoxify pollutants before they can reach the developing child. Many complications of pregnancy have been linked with poor glutathione levels.
Early Human Development 37: 167-174, 1994
Important Notice: These statements have not been evaluated by the Food and Drug Administration. These products are not intended for use in the treatment of any disease.
The body is a complex machine.
Even from within the smallest constituent of the human body, the cell, you can see the intricate system by which the body acts upon to be able to allow us to do the many things we do in our daily lives. Each cell is a machine on its own, continuously synthesizing small compounds which the body uses, to form energy, to create compounds needed by the body to maintain its structure, or to fight against disease or infection. One of the molecules the cells make is glutathione.
Without glutathione, our bodies would be vulnerable and weak.
This is because glutathione has a protective function over the body. Its main function is to act as the body’s most powerful antioxidant, by preventing the damage that can be caused by free radicals. Free radicals have the capability to destroy normal cells of the body since they do not choose the compounds they react to. Glutathione has a lot of reserve electrons by which free radicals can react with, thus sparing the normal cells and preventing their damage or destruction. In effect, glutathione is able to neutralize the free radicals and render them less injurious to normal cells.
Another function of glutathione is as a detoxifier and eliminator of harmful substances in the body. Presence of these substances can cause disease or render vital organs of the body susceptible to attack and damage. Add to this the decreased immune function without glutathione, leading to increased possibility of invasion by other attackers, such as bacteria or viruses. Increased risk and progression of tumors can occur rapidly with low levels of glutathione.
Where do we get glutathione? Glutathione is produced in the liver and is made up of glutamic acid, glycine and cysteine. With the exception of cysteine, these amino acids are easy to obtain naturally because it can be found in many different kinds of fruits and vegetables. Cysteine is the most difficult to find in natural foods, which is why it is one of the basic components being supplied by oral glutathione supplements. To know more about these visit MaxOneMaxGXL.com
MaxOne and MaxGXL are Patented High Performance Formulas which Increase Cellular Glutathione
Robert Keller MD, MS, FACP, has been named as one of the world’s 2,000 Outstanding Scientists of the 21st Century, and has served on the scientific review panels for the National Institutes of Health and the Veterans Administration.
Dr. Keller has served on the faculties of the Mayo Graduate School of Medicine, the University of Wisconsin and the Medical College of Wisconsin (Marquette Univ.) He has published more than 100 original articles in various scientific and medical journals and has been awarded several patents. Dr Keller was elected to The Board of Governors of the American Academy of HIV medicine, and serves on the Scientific Advisory Board of several Biotech companies. The Consumers’ Research Council has named Dr. Keller one of America’s “Top Physicians in 2003, 2004 and 2005 in the fields of Internal Medicine, Immunology and Hematology. Dr. Keller continues his medical practice and research activities at his clinic and laboratory in Florida and is Chairman of the Board and Chief Scientific Officer of Phoenix Biosciences, Inc.